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Density-Functional Fluctuation theory of Crowds
- Determining the laws governing crowd distributions is a key objective of collective population behaviour studies
- The resulting theory offers quantification of crowd “mood” and accurately predicts experimental fly distributions in novel environments.
- A model crowd consisting of walking fruit flies and extract two functions that separately describe spatial and social preferences.
Synthetic Morphology with Agential Materials
- Bioengineering can address many important needs, from transformative biomedicine to environmental remediation.
- In addition to practical applications, the construction of new living systems will increase our understanding of biology
- And will nurture emerging intersections between biological and computational sciences.
Computational Modeling of DLBCL predicts response to BH3-mimetics
- In healthy cells, pro- and anti-apoptotic BCL2 family and BH3-only proteins are expressed in a delicate equilibrium.
- this homeostasis is frequently perturbed in cancer cells due to the overexpression of anti-apoptotic BCL2 family proteins.
- Successful deployment of BH3-mimetics in DLBCL requires reliable predictions of which lymphoma cells will respond.
Membrane protein-regulated networks across human cancers
- Membrane proteins (MPs) play a key role in mediating intercellular communication
- Transducing signals in cells through interacting proteins and downstream cellular processes1.
- And regulated pathways to provide MP-based gene sets for locating prognostic biomarkers and druggable targets.
Designing minimal genomes using whole-cell models
- In the future, entire genomes tailored to specific functions and environments could be designed using computational tools.
- However, computational tools for genome design are currently scarce.
- For genome engineering and design, minimal genomes are currently the best proof-of-concept
Design principles of collateral sensitivity-based dosing strategies
- Antimicrobial resistance is a worldwide health threat due to the reduction of clinically effective antibiotics.
- Current drug discovery pipelines of new-in-class antibiotic agents are insufficient to offset the emergence of new AMR1.
- Innovative strategies to reduce the rate that AMR develops are thus critically needed.
Discovering small-molecule Senolytics with deep Neural Networks
- The accumulation of senescent cells is associated with aging, inflammation and cellular dysfunction.
- Senolytic drugs can alleviate age-related comorbidities by selectively killing senescent cells.
- Results highlight the potential of using deep learning to find senotherapeutics.
3D mapping of intra-articular calcaneal fractures
- To determine the pattern of intra-articular calcaneal fractures (ICFs) by a three-dimensional NUM0D) mapping
- The cohort included 26 (38.8%) left calcaneal fractures, 27 (40.30%) right calcaneal fractures, and 14 (20.9%) cases with bilateral fractures.
- The mean angle of fracture lines concerning the LAC was 11° in the axial wall.
Large-scale, quickly-repaired sublethal damage is caused by high-LET radiation
- Different doses and temporal separations of X-rays, alpha particles, or combinations were applied to cells.
- There is agreement that high-LET radiation has a high Relative Biological Effectiveness (RBE) when delivered as a single treatment.
- But how it interacts with radiations of different qualities, such as X-rays, is less clear.
AMPK and MTOR crosstalk in Glutamatergic Synapse Calcium Signaling
- For the synapses to process information and create memories, neurons must expend energy.
- Only 2% of the mass of the human body is made up of the brain, but it uses almost 20% of the body’s total energy.
- The prediction will cause an up to NUM0 perturbation in AMPK and mTOR oscillations at higher magnitudes.
